These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Combination of arteriovenous extracorporeal lung assist and high-frequency oscillatory ventilation in a porcine model of lavage-induced acute lung injury: a randomized controlled trial.
    Author: Brederlau J, Muellenbach R, Kredel M, Kuestermann J, Anetseder M, Greim C, Roewer N.
    Journal: J Trauma; 2007 Feb; 62(2):336-46; discussion 345-6. PubMed ID: 17297323.
    Abstract:
    BACKGROUND: To compare the combined effects of arteriovenous extracorporeal lung assist (AV-ECLA) and high-frequency oscillatory ventilation (HFOV) on pulmonary gas exchange, hemodynamics, and respiratory parameters in a lavage-induced porcine lung injury model. METHODS: A prospective, randomized animal study. Saline lung lavage was performed in 33 healthy female pigs, weighing 52 +/- 4.1 kg (mean +/- SD), until the Pao2 decreased to 53 +/- 8 mm Hg. After a stabilization period of 60 minutes, the animals were randomly assigned to four groups: group 1, pressure-controlled ventilation (PCV) with a tidal volume of 6 mL/kg; group 2, PCV with a tidal volume of 6 mL/kg and AV-ECLA; group 3, HFOV; group 4, HFOV and AV-ECLA. In groups 2 and 4, the femoral artery and vein were cannulated and a low-resistance membrane lung was interposed. After isolated evaluation of AV-ECLA, the mean airway pressure was increased by 3 cm H2O from 16 to 34 cm H2O every 20 minutes, accompanied by blood gas analyses and measurements of respiratory and hemodynamic variables. RESULTS: Only in AV-ECLA-treated animals was normocapnia achieved. No significant increase of Pao2 attributable to AV-ECLA alone was detected. Mean airway pressure augmentation resulted in a significant increase in Pao2 in all groups. Peak inspiratory pressure was significantly lower in HFOV-treated animals. CONCLUSIONS: The combination of AV-ECLA and HFOV resulted in normocapnia and comparable Pao2, although a smaller ventilator pressure amplitude was applied. Long-term animal studies are needed to assess whether this approach results in further lung protection.
    [Abstract] [Full Text] [Related] [New Search]