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  • Title: Auditory efferent activation in CBA mice exceeds that of C57s for varying levels of noise.
    Author: Frisina RD, Newman SR, Zhu X.
    Journal: J Acoust Soc Am; 2007 Jan; 121(1):EL29-34. PubMed ID: 17297823.
    Abstract:
    The medial olivocochlear efferent (MOC) system enhances signals in noise and helps mediate auditory attention. Contralateral suppression (CS) of distortion product otoacoustic emissions (DPOAEs) has revealed age-related MOC declines. Here, differences in CS as a function of contralateral noise intensity (43-67 dB sound pressure level) were measured; 2f1-f2 DPOAE grams were recorded for young adult CBA and C57 mice. In CBAs, CS was a monotonic function of contralateral noise level. The C57s showed normal hearing, measured with DPOAE amplitudes and auditory brainstem response thresholds, but showed little CS, suggesting a loss of efferent dynamics preceding any deficiencies of the afferent auditory system.
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