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  • Title: [Influence of perinatal complications on serum levels of alpha 1-antitrypsin in preterm newborns].
    Author: Brkić S, Skokić F, Mladina N.
    Journal: Med Arh; 2006; 60(6):347-50. PubMed ID: 17297846.
    Abstract:
    Influence of perinatal complications on serum levels of alpha 1-antitrypsin was investigated in preterms newborns. Investigation was performed on two groups of newborns: first group consisted of 40 preterm newborns (gestation below 37 weeks) with perinatal complications, and second group consisted of 40 newborns without perinatal complications (gestation 37-42 weeks). Values of al-AT in serum preterm newbornswere 1,76+/-0,48 g/l, and in health newborns 1,88+/-0,31 g/l. Statistically significant difference was noted between two investigated serum values (p<0,0008). There was not a statistically significant influence of sex of investigated newborns in serum levels of alpha1-AT. From all investigated perinatal complications (RDS, brain damage, infection, deviation of intrauterine growth, ruptura vela filamentorum, vitium cordis congenita and more complications) variable "infection" has had only statistically significant influence on serum levels alpha1-AT (p< 0,02). T he opinion o f authors of th is investigation is that serum levels of this protein could be usefull in a diagnostic purposes, even if antibiotic treatment was started, and it will be a usefull as an early marker of pure treatment some of diseases.
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