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  • Title: In vivo recovery and survival of red cells after photodynamic treatment with thiopyrylium and red light using a canine model.
    Author: Skripchenko A, Balch A, Mackin A, Wagner SJ.
    Journal: Vox Sang; 2007 Feb; 92(2):157-9. PubMed ID: 17298580.
    Abstract:
    Recently, we have shown that thiopyrylium has robust inactivation capabilities against a broad spectrum of pathogens in the human red blood cell (RBC) suspensions while retaining key RBC in vitro properties. The 24-h recovery and survival of canine red cells were measured upon autologus reinfusion of control and phototreated units. The 24-h recovery of control and phototreated RBCs was 75.7 +/- 6.4% and 87.5 +/- 8.5%, respectively. The time for 50% survival of labelled control RBCs was similar to that of phototreated group (206 +/- 58 h vs. 255 +/- 63 h, respectively). Results suggest that thiopyrylium phototreatment does not negatively affect canine RBC in vivo recovery.
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