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  • Title: Cushing syndrome from percutaneous absorption of 1% hydrocortisone ointment in Netherton syndrome.
    Author: Halverstam CP, Vachharajani A, Mallory SB.
    Journal: Pediatr Dermatol; 2007; 24(1):42-5. PubMed ID: 17300648.
    Abstract:
    Netherton syndrome is a congenital skin disease associated with decreased skin barrier function and increased percutaneous absorption. We report an 11-year-old boy with Netherton syndrome who developed Cushing syndrome after application of 1% hydrocortisone ointment to his entire body for more than 1 year. This presentation illustrates that even low-potency steroid ointments should be used with caution in Netherton syndrome and warns about the use of long-term topical medications with potential systemic side effects when used in large quantities in any chronic skin disease.
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