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  • Title: Durable neutralizing antibodies after remote smallpox vaccination among adults with and without HIV infection.
    Author: Kan VL, Manischewitz J, King LR, Golding H.
    Journal: AIDS; 2007 Feb 19; 21(4):521-4. PubMed ID: 17301573.
    Abstract:
    The only US licensed vaccine with established efficacy against smallpox, Dryvax, is contraindicated for HIV patients. Detectable smallpox-neutralizing antibodies are still present among US adults. This study compared vaccinia-neutralizing antibody titers between 20 HIV-infected and 20 uninfected veterans matched for age and military entry. Vaccinia-neutralizing antibodies were detected in 95% HIV-infected and 100% uninfected veterans; 40% HIV-infected and 70% uninfected adults had protective titers. Therefore, after robust vaccination, neutralizing antibodies are maintained for prolonged times despite CD4 cell depletion.
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