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  • Title: [Detection of anti-Sp17 antibodies in infertile patients' serum and its clinical significance].
    Author: Zhang CH, Li FQ, Yang AL, Sun W, Miao JW.
    Journal: Zhonghua Nan Ke Xue; 2007 Jan; 13(1):27-9. PubMed ID: 17302030.
    Abstract:
    OBJECTIVE: To test anti-Sp17 antibodies in the serum of AsAb positive infertile patients, to investigate the proportion of anti-Spl7 antibodies in AsAb and their potential application to the serologic diagnosis of immune infertility and immunocontraception. METHODS: With human recombinant Sp17 as the antigen, the ELISA method was used to detect the positive rate, antibody titre and content of anti-Sp17 antibodies in the AsAb positive serum. RESULTS: The positive rate of anti-Sp17 antibodies in the AsAb positive serum was 56.5%, with no significant difference in the gender aspect. The percentage of anti-Sp17 antibodies in AsAb was (10.09 +/-7.45) %, with statistical significance (P <0.05). CONCLUSION: Sp17 is an important sperm antigen. Anti-Sp17 antibodies in the serum can be taken as auxiliary diagnostic index of infertility, and Sp17 is shown to be a potential candidate immunocontraception vaccine.
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