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  • Title: Significance of late recurrence of atrial fibrillation during long-term follow-up after pulmonary vein isolation.
    Author: Solheim E, Hoff PI, Off MK, Ohm OJ, Chen J.
    Journal: Pacing Clin Electrophysiol; 2007 Jan; 30 Suppl 1():S108-11. PubMed ID: 17302683.
    Abstract:
    BACKGROUND AND STUDY OBJECTIVE: Patients with paroxysmal or persistent atrial fibrillation (AF) can be treated by pulmonary vein (PV) isolation. Although the recurrence rate after the procedure is relatively high, the long-term outcomes after initially recurrence-free procedures remains unclear. We examined the rates of recurrence of AF after PV isolation. METHODS: Our study included 278 consecutive patients with drug-refractory AF (mean age = 53 +/- 11 years, 228 men). PV isolation was based on the disappearance of PV potentials recorded from a circumferential catheter after segmental ostium ablation. Cavo-tricuspid isthmus lines and additional atrial lines were performed in 124 and 28 patients, respectively. Patients were monitored for a mean of 26 +/- 11 months (range 12-56). Recurrence was defined as >/= 1 episodes of symptomatic or asymptomatic AF > 1 month after the procedure. RESULTS: A total of 120 (34) patients had >/= 1 recurrence of AF > 1 month after the procedure, of whom 14 (4) had a first recurrence > 6 months after the procedure. There was a significantly higher recurrence rate among patients with persistent AF. CONCLUSIONS: A relatively high AF recurrence rate was observed after PV isolation. AF may recur late after the ablation procedure, though the majority of recurrences occurred within 6 months after the first procedure. There were no differences in incidence or time of occurrence of late recurrences between patients with paroxysmal versus persistent AF.
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