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  • Title: [Biomimetics of crystal texture in dental enamel prism by self-assembly oligopeptide].
    Author: Wang L, Bai W, Feng HL, Jia XR.
    Journal: Beijing Da Xue Xue Bao Yi Xue Ban; 2007 Feb 18; 39(1):46-9. PubMed ID: 17304326.
    Abstract:
    OBJECTIVE: To evaluate the possibility of self-assembly oligopeptide(T2) for dental enamel biomimetics, especially for the prism's crystal texture since it could prompt calcium phosphate precipitated in gel carrier. METHODS: SEM (Scanning electron microscope) and TEM (Transmission electron microscope) were used to observe the morphologic presentation and ED(Electron diffraction) to crystal texture comparing with the human molar enamel powder. RESULTS: (a) Flake-like and needle-like octacalcium phosphate precipitated in the gel carrier with self-assemble oligopeptide(T2). They transformed into rod-like hydroxyapatite crystals gradually in the following 2-4 weeks. (b) The rod-like hydroxyapatite may arrange or grow into bundles which are similar to the human enamel prisms in both appearance and size. (c) The rod-like hydroxyapatite showed polycrystal while the enamel prisms showed monocrystal under examination of ED. CONCLUSION: The self-assemble oligopeptide(T2) could regulate the speed of nucleation and crystallization of hydroxyapatite in morphology and crystalline size. Thus, the self-assembly oligopeptide and the gel carrier mineralization system could be primarily applied in biomimetic use for the crystallization of hydroxyapatite in dental prism in vitro.
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