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  • Title: Effect of age on the development of a latanoprost-induced increase in iris pigmentation.
    Author: Arranz-Marquez E, Teus MA.
    Journal: Ophthalmology; 2007 Jul; 114(7):1255-8. PubMed ID: 17306877.
    Abstract:
    PURPOSE: To study the effect of patient age on the incidence of latanoprost-induced increases in iris pigmentation. DESIGN: Prospective observational observer-masked study. PARTICIPANTS: Thirty-six patients younger than 60 years (group 1) and 36 patients older than 75 years (group 2) with primary open-angle glaucoma. METHODS: We photographed both irises of each patient before and 6 months after unilateral latanoprost therapy. The basal iris colors were matched in both groups. MAIN OUTCOME MEASURES: Iris heterochromia identification at the 6-month evaluation of the photographs. RESULTS: Twenty-eight patients (77.78%) in group 2 developed an increase in iris pigmentation compared with eight patients (22.22%) in group 1 (P = 0.0001, chi-square test). CONCLUSIONS: Age seems to be an important risk factor for latanoprost-induced iris color change.
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