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  • Title: Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase.
    Author: Liang G, Klose RJ, Gardner KE, Zhang Y.
    Journal: Nat Struct Mol Biol; 2007 Mar; 14(3):243-5. PubMed ID: 17310254.
    Abstract:
    Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.
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