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  • Title: IL-15 an immunoregulatory and anti-cancer cytokine. Recent advances.
    Author: Shanmugham LN, Petrarca C, Frydas S, Donelan J, Castellani ML, Boucher W, Madhappan B, Tete' S, Falasca K, Conti P, Vecchiet J.
    Journal: J Exp Clin Cancer Res; 2006 Dec; 25(4):529-36. PubMed ID: 17310844.
    Abstract:
    Interleukins are mediators of inflammation, immunity and cancer. IL-15 is a cytokine produced by several leukocytes including phagocytes in response to infections and other signals that trigger innate immunity. IL-15 has many homologies to interleukin-2 (IL-2) and like IL-2, stimulates NK cells. This cytokine acts also on memory CD8+ T-cell. IL-15, therefore acts, probably through selective inhibition of tumor promoting molecules, as a new compound for the adjuvant treatment of solid tumors. In this review we propose a newly revised mechanism of interleukin 15 in inflammation and cancer.
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