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  • Title: [Characterization of HIV-1 Gag-specific proliferative T cell responses in Chinese HIV-1 infected patients].
    Author: Wang Q, Shang H, Wang YN, Zhang ZN, Jiang YJ.
    Journal: Zhonghua Yi Xue Za Zhi; 2006 Nov 28; 86(44):3099-103. PubMed ID: 17313759.
    Abstract:
    OBJECTIVE: To investigate the characteristics of HIV-1 Gag-specific T lymphocyte proliferative responses in Chinese HIV infected patients, analyze their associations with disease progression and explore the mechanism of the HIV-specific immune dysfunction in HIV infection. METHODS: Specific proliferative responses of PBMC from thirty four HIV-1 infected patients to HIV-1 Gag antigen were detected by a BrdU incorporated flow cytometry intracellular stain, their relations with CD4(+) T cells absolute counts, plasma viral loads and CD8(+) T cell activate status were analyzed. RESULTS: HIV-1 Gag-specific CD4(+) T cell proliferative responses of HIV-infected patients were significantly lower than that of healthy controls (P < 0.01), correlated inversely to CD38 expression on CD8(+) T lymphocytes and plasma viral loads (P < 0.05, P < 0.05), and directly to CD4(+) T cell absolute counts (P < 0.01). HIV-1 Gag-specific CD8(+) T cell proliferative responses of HIV-infected patients were significantly higher than that of healthy controls (P < 0.01), correlated directly to CD38 expression on CD8(+) T lymphocytes (P < 0.05), and inversely to CD4(+) T cell absolute counts (P < 0.01), but not correlated to viral loads (P > 0.05). CONCLUSION: HIV-1 Gag-specific T cell proliferative response were abnormal in Chinese HIV-1 infected persons, HIV-1 Gag-specific CD4(+) T cell proliferative responses were decreased and their frequencies were closely correlated with disease progression.
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