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  • Title: Reverse gyrase: an insight into the role of DNA-topoisomerases.
    Author: Nadal M.
    Journal: Biochimie; 2007 Apr; 89(4):447-55. PubMed ID: 17316953.
    Abstract:
    Reverse gyrase was discovered more than twenty years ago. Recent biochemical and structural results have greatly enhanced our understanding of their positive supercoiling mechanism. In addition to new biochemical properties, a fine tuning of reverse gyrase regulation in response to DNA damaging agents has been recently described. These data give us a new insight in the cellular role of reverse gyrase. Moreover, it has been proposed that reverse gyrase has been implicated in genome stability.
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