These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Conservative treatment in patients with unilateral retinoblastoma].
    Author: Rutynowska-Pronicka O, Hautz W, Brozyna A, Dembowska-Bagińska B, Drogosiewicz M, Stypińska M, Perek D.
    Journal: Med Wieku Rozwoj; 2006; 10(3 Pt 1):655-63. PubMed ID: 17317897.
    Abstract:
    UNLABELLED: THE AIM of our study was to evaluate results of conservative treatment of patients with unilateral retinoblastoma. MATERIAL AND METHODS: Twenty one patients, 11 boys and 10 girls aged 2 months to 4, 5 years (median age 1 year) were studied. Local disease advancement according to Reese-Elsworth was defined in all patients. Neoadjuvant chemotherapy consisting of Vincristine, Etoposide and Carboplatin was administered. After every 2 courses tumour response was evaluated. Sixteen patients were treated with chemotherapy alone. Local treatment including brachytherapy, thermochemotherapy and cryotherapy was implemented and the choice of the method depended on the tumour's localization, size and response to chemotherapy. Statistical analysis using demographic data and survival curves were performed. RESULTS: On completion of treatment all patients achieved tumour regression. Eleven patients are progression free with a follow-up from 10 months to 6 years 4 months (median--2 yrs 5m). In 10 patients relapse was observed. A total of seven enucleations were performed in the examined group. In histopathological examination viable tumour cells were present in all removed eye balls. Distant metastases were not observed in any of these patients. All patients are alive with a follow-up from 10 months to 9 yrs 6 months (median--4 yrs 7 months) from diagnosis. Disease free survival and ocular survival is 44% and 54% respectively. CONCLUSION: Neoadjuvant chemotherapy in unilateral retinoblastoma allows to avoid enucleation in some patients.
    [Abstract] [Full Text] [Related] [New Search]