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  • Title: Actin molecules promote neurite outgrowth of chick telencephalic neurons in vitro.
    Author: Nobusada H, Taguchi T.
    Journal: Biochem Biophys Res Commun; 1992 Jan 15; 182(1):39-44. PubMed ID: 1731797.
    Abstract:
    Chick brain extract contains protein factors for neurite outgrowth from embryonic chick telencephalic neurons in dissociated cell cultures. In the course of purification of the factors using a bioassay system, a 41 kDa protein was detected to be one of the factors. Immunoblot analysis showed that this protein is identical to actin. In addition, G-actin purified from rabbit skeletal muscle exhibits neurite outgrowth activity in the same dose-dependent manner as the 41 kDa protein. The same bioassay carried with other purified proteins did not show such a remarkable activity.
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