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  • Title: Endoluminal clip closure of a circular full-thickness colon resection in a porcine model (with videos).
    Author: Raju GS, Ahmed I, Shibukawa G, Poussard A, Brining D.
    Journal: Gastrointest Endosc; 2007 Mar; 65(3):503-9. PubMed ID: 17321256.
    Abstract:
    BACKGROUND: Linear perforations of the colon can be closed by the application of clips through a colonoscope. It is unclear whether circular perforations after full-thickness resection of the colon can be closed with clips. OBJECTIVE: To develop an animal model for circular perforation of the colon and to study different techniques to accomplish a leakproof sealing of the circular perforation of the colon. DESIGN: Pilot study. SETTING: University medical center. ANIMALS: Ten pigs: 2 perforations in the 1st pig and 1 perforation in the 2nd to 9th pigs were closed with clips. In the 10th pig, 5 perforations were created, and the dimensions of the perforation were measured. INTERVENTIONS: Creation of a circular full-thickness resection of the colon with a band-ligation-resection device, followed by longitudinal or transverse endoluminal closure of the perforation by using the first clip opened and applied in the 3- to 9-o'clock or the 6- to 12-o'clock direction in relation to the circular perforation, respectively. MAIN OUTCOME MEASUREMENTS: The mean (standard deviation) size of circular perforation was 1.7 +/- 0.075 cm (range, 1.5-2.0 cm). Necropsy immediately after closure of the perforation was done to examine the closure and to confirm the quality of sealing with the methylene blue dye leak test. RESULTS: The transverse closure was unsuccessful in the closure of 3 perforations, whereas the longitudinal closure resulted in a leakproof sealing in 6 of the 7 closures. LIMITATIONS: Perforation of the adjacent viscera limits it to a nonsurvival study. CONCLUSIONS: Endoluminal application of clips by using the longitudinal closure technique results in a leak proof sealing of circular perforations of the colon.
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