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  • Title: Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion.
    Author: Cherrill DA, Stote RM, Birge JR, Singer I.
    Journal: Ann Intern Med; 1975 Nov; 83(5):654-6. PubMed ID: 173218.
    Abstract:
    We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion.
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