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  • Title: Role of acetylcholine receptor antibody complexes in muscle in experimental autoimmune myasthenia gravis.
    Author: Verschuuren JJ, Graus YM, Theunissen RO, Yamamoto T, Vincent A, van Breda Vriesman PJ, De Baets MH.
    Journal: J Neuroimmunol; 1992 Feb; 36(2-3):117-25. PubMed ID: 1732277.
    Abstract:
    In experimental autoimmune myasthenia gravis anti-rat nicotinic acetylcholine receptor (AChR) antibody titers correlated significantly with the AChR-antibody complexes found in muscle. It was shown that at least a large part of the AChR-antibody complexes are formed in vitro, which can be prevented by washing of the muscle homogenate. Using a modified assay, no differences in AChR-antibody complexes could be detected between rats with and without symptoms of experimental autoimmune myasthenia gravis. Also no difference in AChR loss nor in inhibition of alpha-bungarotoxin binding to AChR was found between these groups of rats. However, a significant difference in the reduction of AChR function was found, using an assay measuring agonist-induced 22Na+ flux into the TE671 cell line.
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