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  • Title: Identification of Candida tenuis xylose reductase as highly selective biocatalyst for the synthesis of aromatic alpha-hydroxy esters and improvement of its efficiency by protein engineering.
    Author: Kratzer R, Nidetzky B.
    Journal: Chem Commun (Camb); 2007 Mar 14; (10):1047-9. PubMed ID: 17325801.
    Abstract:
    Wild-type Candida tenuis xylose reductase and two Trp-23 mutants thereof catalyze NADH-dependent reduction of a homologous series of aromatic alpha-keto esters with absolute pseudo re-face stereoselectivity and broad tolerance for the substituent on the aromatic ring, producing the corresponding R-alcohols in high yield.
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