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  • Title: Electrochemically addressable functionalization and parallel readout of a DNA biosensor array.
    Author: Niu L, Knoll W.
    Journal: Anal Chem; 2007 Apr 01; 79(7):2695-702. PubMed ID: 17326609.
    Abstract:
    We introduce an electrochemical method for the directed in situ assembly of various specific oligonucleotide capture probes onto different sensing elements of a multielectrode array in the aqueous environment of a flow cell. Surface plasmon microscopy is utilized for the on-line recording of the various functionalization steps. Hybridization reactions between targets from solution to the different surface-bound complementary probes are monitored by surface plasmon field-enhanced fluorescence microscopy using targets that are either labeled with organic dyes or with semiconducting quantum dots for color-multiplexing. This study provides a new approach for the fabrication of (small) DNA arrays and the recording and quantitative evaluation of parallel hybridization reactions.
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