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  • Title: Levetiracetam intravenous infusion as an alternative to oral dosing in patients with partial-onset seizures.
    Author: Baulac M, Brodie MJ, Elger CE, Krakow K, Stockis A, Meyvisch P, Falter U.
    Journal: Epilepsia; 2007 Mar; 48(3):589-92. PubMed ID: 17326794.
    Abstract:
    PURPOSE: This multicenter, open-label study evaluated the short-term tolerability of intravenously (IV)-infused levetiracetam (LEV; 500-1,500 mg/100 ml, 15 min, b.i.d.) as a substitute for the same oral dose. METHODS: The study consisted of screening, 4-day IV LEV and 1-7 days of follow-up, and was conducted in 25 adults with partial-onset seizures receiving adjunctive oral LEV. RESULTS: During the 4-day IV LEV, 11 (44%) subjects experienced at least one treatment-emergent adverse event (TEAE), with headache and fatigue being the most frequently reported. Five (20%) subjects experienced TEAEs considered to be related to the study drug. The tolerability profile was consistent with that of oral LEV, with all events judged mild or moderate in severity, no discontinuations, and no serious AEs or deaths reported. No AE related to seizure worsening was reported during IV LEV or brief follow-up. CONCLUSIONS: LEV IV appears to be a well-tolerated, practical alternative in patients with partial-onset seizures temporarily unable to take the drug orally.
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