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  • Title: Pituitary adenylate cyclase activating polypeptide stimulates insulin release from the isolated perfused rat pancreas.
    Author: Kawai K, Ohse C, Watanabe Y, Suzuki S, Yamashita K, Ohashi S.
    Journal: Life Sci; 1992; 50(4):257-61. PubMed ID: 1732697.
    Abstract:
    Pituitary adenylate cyclase activating polypeptide (PACAP) is a novel hypothalamic peptide structurally related to vasoactive intestinal peptide (VIP) and glucagon like peptide-1(7-36) amide (tGLP-1) in its N-terminal portion. Therefore, their levels of insulinotropic potency were compared using an isolated rat pancreas perfusion. It was found that 0.1 nM PACAP (1-27) amide (PACAP27) significantly stimulated insulin release under a perfusate glucose concentration of 5.5 mM, whereas 1 nM PACAP27 did not under a perfusate glucose concentration of 2.8 mM. The potency was evaluated as tGLP-1 greater than PACAP27 greater than VIP. These results indicate that PACAP is a glucagon superfamily peptide which stimulates insulin release in a glucose dependent manner.
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