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  • Title: Drug evaluation: OPT-80, a narrow-spectrum macrocyclic antibiotic.
    Author: Johnson AP.
    Journal: Curr Opin Investig Drugs; 2007 Feb; 8(2):168-73. PubMed ID: 17328233.
    Abstract:
    Optimer Pharmaceuticals Inc, in collaboration with Par Pharmaceutical Companies Inc, is developing OPT-80, a narrow-spectrum macrocyclic antibiotic secreted by the actinomycete Dactylosporangium aurantiacum, for the potential treatment of Clostridium difficile-associated diarrhea (CDAD) and vancomycin-resistant Enterococcus infection. A phase IIb/III clinical trial of OPT-80 in patients with CDAD is underway.
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