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  • Title: Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.
    Author: Zhang M, Tamiya J, Nguyen L, Rowbottom MW, Dyck B, Vickers TD, Grey J, Schwarz DA, Heise CE, Haelewyn J, Mistry MS, Goodfellow VS.
    Journal: Bioorg Med Chem Lett; 2007 May 01; 17(9):2535-9. PubMed ID: 17329101.
    Abstract:
    A series of thienopyrimidinone bis-aminopyrrolidine ureas were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor-1. These compounds exhibit potent binding affinity (K(i)=3 nM) and good in vitro metabolic stability.
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