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  • Title: Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors.
    Author: Eary CT, Jones ZS, Groneberg RD, Burgess LE, Mareska DA, Drew MD, Blake JF, Laird ER, Balachari D, O'Sullivan M, Allen A, Marsh V.
    Journal: Bioorg Med Chem Lett; 2007 May 01; 17(9):2608-13. PubMed ID: 17331716.
    Abstract:
    Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterol ester between lipoprotein particles. Inhibition of this protein, in vitro and in vivo, produces an increase in plasma high density lipoprotein cholesterol (HDL-C). This communication will describe the SAR and synthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors from early mu lead to advanced enantiomerically pure analogs.
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