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  • Title: Measles seroepidemiology among adolescents and young adults: response to revaccination.
    Author: Saffar MJ, Alraza-Amiri M, Ajami A, Baba-Mahmoodi F, Khalilian AR, Vahidshahi C, Shamsizadeh A.
    Journal: East Mediterr Health J; 2006 Sep; 12(5):573-81. PubMed ID: 17333796.
    Abstract:
    We evaluated the seroprevalence of measles antibody and response to measles reimmunization in 590 previously vaccinated adolescents and young adults; 263 were seronegative. To differentiate between primary and secondary vaccine failure, anti-measles IgM and IgG titres were assessed again 2-4 weeks after revaccination in 144 (105 seronegative, 39 seropositive) individuals: 75 seronegative participants responded to revaccination anamnestically (P < 0.001) and developed immunity, 11 also showed IgM response (probably primary vaccine failure); 38 seropositive participants remained seroprotected without significant increase in antibody titre (P = 0.577). Primary vaccine failure was 4.7%; secondary vaccine failure was 27.1%. After revaccination, 87.3% were seroprotected.
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