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  • Title: Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model.
    Author: Singh FV, Chaurasia S, Joshi MD, Srivastava AK, Goel A.
    Journal: Bioorg Med Chem Lett; 2007 May 01; 17(9):2425-9. PubMed ID: 17336063.
    Abstract:
    Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2-one and 6-(furan-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded streptozotocin-induced diabetic rat model. Five of the test compounds showed significant lowering of plasma glucose level in STZ-S model.
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