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  • Title: Synthesis and biological evaluation of novel analogues of dictyostatin.
    Author: Paterson I, Gardner NM, Poullennec KG, Wright AE.
    Journal: Bioorg Med Chem Lett; 2007 May 01; 17(9):2443-7. PubMed ID: 17336522.
    Abstract:
    Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the structurally related discodermolide, synthesised by a late-stage diversification strategy and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including those known to exhibit Taxol-resistance (AsPC-1, DLD-1, PANC-1, NCI/ADR).
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