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  • Title: [Solitary fibrous tumor: a clinico-morphological and immunohistochemical study].
    Author: Leenman EE, Popov SD, Dvorakovskaia IV, Arsen'ev AI, Pozharisskiĭ KM.
    Journal: Vopr Onkol; 2006; 52(6):624-32. PubMed ID: 17338238.
    Abstract:
    Solitary fibrous tumor is a rare neoplasm which may occur at any site although it is more frequent in the pleura, mediastinum and lung. The study used 4 cases of tumor localization in the pleura and orbit. Three cases presented as a "hemangiopericytic" variety of spindle cells; there were numerous giant cells in orbit tumor. Solitary fibrous tumor revealed enhanced expression of vimentin, CD34, bel-2 and CD99. Expression of S-100, desmine and non-striated muscle actin was found in few cells in some cases. Such features as large size (over 10 cm), necrosis, high cellularity, nuclear polymorphism and high mitotic index (more than 4 mitoses within 4 visual fields, at high magnification) were used as malignancy criteria:. Tumor histological pattern of "hemangiopericytic" variety could be reliably identified thanks to immunohistochemical procedure.
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