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  • Title: [Gas chromatography with mass-selective detector in testing blood for amitriptyline and nortriptyline].
    Author: Melent'ev AB, Kataev SS, Ivanova EP.
    Journal: Sud Med Ekspert; 2007; 50(1):31-4. PubMed ID: 17338340.
    Abstract:
    The article describes the method of simultaneous detection of amitriptiline and nortriptilin in cadaveric blood using gas chromatography with mass-selective detection. Preparation includes liquid-liquid extraction and derivation with trifluoroacetic anhydride. Nortriptilin threshold of detectability in the blood is 0.02 mcg/ml, amitriptilin one--0.05 mcg/ml. The range of detectability--0.05-3.0 mcg/ml for both compounds. Maximal error of the compounds detectability was under 12.9% for concentrations 0.10 mcg/ml and 10.6% for concentrations 2.0 mcg/ml. The method was tested on expert material in forensic chemical examinations.
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