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  • Title: In vitro efficiency of new acridyl derivatives against Plasmodium falciparum.
    Author: Guetzoyan L, Ramiandrasoa F, Dorizon H, Desprez C, Bridoux A, Rogier C, Pradines B, Perrée-Fauvet M.
    Journal: Bioorg Med Chem; 2007 May 01; 15(9):3278-89. PubMed ID: 17339112.
    Abstract:
    A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC50 <or= 0.20 microM.
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