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  • Title: MK801 antagonism of the prolonged depletion of striatal dopamine by amphetamine in iprindole-treated rats.
    Author: Hemrick-Luecke SK, Henderson MG, Fuller RW.
    Journal: Life Sci; 1992; 50(6):PL31-3. PubMed ID: 1734157.
    Abstract:
    The administration of amphetamine to rats pretreated with iprindole to inhibit the metabolism of amphetamine results in a long-lasting depletion of striatal dopamine and its metabolites, DOPAC and HVA. Pretreatment with MK801, a noncompetitive antagonist of the NMDA (N-methyl-D-aspartate) subclass of excitatory amino acid receptors, antagonized the depletion of striatal dopamine, DOPAC and HVA 3 days after a single dose of amphetamine in iprindole-treated rats. MK801 pretreatment was effective up to 4 hours but not at 8 or 24 hours in preventing amphetamine effects on striatal dopamine, DOPAC and HVA.
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