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  • Title: [Protamine as a specific inhibitor of electron transport between cytochromes c and a on the outer surface of the mitochondrial membrane].
    Author: Konstantinov AL.
    Journal: Biokhimiia; 1975; 40(2):401-7. PubMed ID: 173421.
    Abstract:
    The basic protein protamine is found to be a potent inhibitor of mitochondrial cytochrome c oxidase, while the oxidase activity of the "inside out" submitochondrial particles is only slightly affected by this polycation. The site of inhibition of mitochondrial respiration by protamine is localized between cytochromes c and a, protamine combining with cytochrome oxidase competitively to cytochrome, c, Ki=2,5 x 10(-6) M. The data obtained suggest that it is the outer side of the mitochondrial membrane where oxidation of cytochrome c by cytochrome a occurs.
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