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  • Title: [Experimental cirrhosis of the liver obtained with simultaneous carbon tetrachloride and phenobarbital sodium].
    Author: Colombo P, Savio S, Cavallero M, Fiaccadori C.
    Journal: Arch Sci Med (Torino); 1973; 130(3):188-97. PubMed ID: 17342914.
    Abstract:
    Phenobarbital sodium considerably increases the liver toxicity of CCl4. The onset and course of cirrhosis induced by simultaneous oral phenobarbital sodium and inhaled CCl4 were studied in a large number of rats. The apparatus and method used are described. The results observed are expressed in terms of survival, variations in liver and spleen weight, and the gross and microscopic liver picture. The method is considered for optimal for the rapid induction of marked and typical cirrhosis in the rat.
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