These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus.
    Author: Wang SC, Lin CH, Ou TT, Wu CC, Tsai WC, Hu CJ, Liu HW, Yen JH.
    Journal: J Rheumatol; 2007 Apr; 34(4):721-5. PubMed ID: 17343323.
    Abstract:
    OBJECTIVE: To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE). METHODS: One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR. RESULTS: The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5, 95% confidence interval 1.4-4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3-2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls. CONCLUSION: PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan.
    [Abstract] [Full Text] [Related] [New Search]