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  • Title: Ovarian cancer activity of cyclic amine and thiaether metal complexes.
    Author: Medvetz DA, Stakleff KD, Schreiber T, Custer PD, Hindi K, Panzner MJ, Blanco DD, Taschner MJ, Tessier CA, Youngs WJ.
    Journal: J Med Chem; 2007 Apr 05; 50(7):1703-6. PubMed ID: 17343369.
    Abstract:
    A thiaether metal complex 1-aza-4,7-dithiacyclononane-RhCl3, 2, and cyclic amine metal complexes tacn-CuBr2, 3, and Me3tacn-RuCl3, 4, have been evaluated for anticancer activity against the ovarian cancer cell line NuTu-19 and for cell toxicity against the noncancerous ovarian tissue cell line OVepi. Specifically, metal complex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cell invasion assay. The in vitro results reported warrant further evaluation of metal complex 2 in living systems.
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