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  • Title: Preparation of a 7-arylthieno[3,2-d]pyrimidin-4-amine library.
    Author: Peng J, Lin W, Jiang D, Yuan S, Chen Y.
    Journal: J Comb Chem; 2007; 9(3):431-6. PubMed ID: 17343423.
    Abstract:
    A focused kinase library of 7-arylthieno[3,2-d]pyrimidin-4-amine analogues is readily prepared via solution-phase parallel synthesis. This strategy relies on a key cyclization of a 3-aminothiophene-2-carboxamide with a formamide to construct the thienopyrimidine core. Further elaborations of this core via substitution and Suzuki coupling reactions allow the introduction of other diversity points. This methodology is demonstrated through the preparation of a 72-membered library of 7-arylthieno[3,2-d]pyrimidin-4-amines in good yields and high purities.
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