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  • Title: Effects of substance P on spontaneous contraction in the flexure region of the guinea pig colon.
    Author: Chowdhury JU, Nahar NS.
    Journal: Mymensingh Med J; 2007 Jan; 16(1):17-9. PubMed ID: 17344773.
    Abstract:
    Effects of Substance P on spontaneous contractions of the circular muscle of the flexure region of guinea pig colon were studied by mechanical tension recording. Substance P (3 nM-10 nM) produced tonic contraction associated with phasic activities but the contraction was found stronger at higher concentration. Verapamil (3 microM), a voltage dependent L-type Ca(2+) channel blocker completely blocked the spontaneous activities and also Substance P induced contraction. These results suggest that Substance P produce contraction by Ca(2+) influx and the Ca(2+) influx occurs by activating verapamil sensitive Ca(2+) channel.
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