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  • Title: [Leydig cell tumor as a cause of hirsutism in a postmenopausal woman].
    Author: Matuszczyk A, Petersenn S, Lahner H, Haude M, Veit P, Becker JU, Kimmig R, Bockisch A, Mann K.
    Journal: Med Klin (Munich); 2007 Mar 15; 102(3):259-62. PubMed ID: 17345023.
    Abstract:
    BACKGROUND: Hirsutism or virilization in postmenopausal women may be due to increased testosterone levels caused by an androgen-secreting tumor. The preoperative localization of small ovarian or adrenal androgen-secreting tumors is difficult. CASE REPORT: A 61-year-old, postmenopausal woman presented with progressive hirsutism and deepening of voice over the last 9 years. Serum testosterone was very high (almost 30 nmol/l). Computed tomographic (CT) scans of the adrenals and ultrasonography of the pelvis were negative. Selective catheterization and [(18)F]FDG-PET/CT investigation raised the suspicion of an androgen-secreting tumor of the right ovary. Oophorectomy was performed, and a Leydig cell tumor of the right ovary was confirmed on histological examination. CONCLUSION: Selective catheterization and [(18)F]FDG-PET investigation may aid the detection of androgen-secreting tumors.
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