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  • Title: Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.
    Author: Cao S, Brodie PJ, Miller JS, Ratovoson F, Birkinshaw C, Randrianasolo S, Rakotobe E, Rasamison VE, Kingston DG.
    Journal: J Nat Prod; 2007 Apr; 70(4):686-8. PubMed ID: 17348706.
    Abstract:
    Bioassay-guided fractionation of the ethanol extract obtained from the fruits of Rheedia calcicola led to the isolation of two new guttiferone analogues, guttiferones K (1) and L (16-hydroxyguttiferone K) (2). The structures of 1 and 2 were established on the basis of extensive interpretation of one- and two-dimensional NMR spectroscopic data. Both compounds were tested for their antiproliferative activity against the A2780 human ovarian cancer cell line.
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