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  • Title: An inv(16) in Ph-negative cells of a chronic myelogenous leukemia patient after imatinib treatment.
    Author: Rowe LR, Brothman AR, Nibley WE, Gaffney MR, Chen Z.
    Journal: Cancer Genet Cytogenet; 2007 Apr 01; 174(1):54-6. PubMed ID: 17350467.
    Abstract:
    Secondary chromosomal changes are known to develop in Philadelphia chromosome-negative (Ph-) cells of chronic myelogenous leukemia (CML) patients after treatment with imatinib mesylate, an ABL kinase inhibitor. We report here a novel case of a pericentric inversion of chromosome 16 as the sole cytogenetic abnormality in Ph- cells after treatment of Ph+ CML with imatinib.
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