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  • Title: Evolution and multilevel optimization of the genetic code.
    Author: Bollenbach T, Vetsigian K, Kishony R.
    Journal: Genome Res; 2007 Apr; 17(4):401-4. PubMed ID: 17351130.
    Abstract:
    The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.
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