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  • Title: Cognitive changes in Parkinson's disease patients with visual hallucinations.
    Author: Ramirez-Ruiz B, Junque C, Marti MJ, Valldeoriola F, Tolosa E.
    Journal: Dement Geriatr Cogn Disord; 2007; 23(5):281-8. PubMed ID: 17351320.
    Abstract:
    OBJECTIVE: To evaluate the decline in specific neuropsychological functions in nondemented Parkinson's disease (PD) patients with a history of visual hallucinations (VH). METHODS: Twenty PD patients with VH, 20 PD patients without VH and 18 normal controls were followed up over a 1-year period and assessed for cognitive decline. RESULTS: Forty-five percent of nondemented hallucinating PD patients developed dementia during the 1-year period between baseline and follow-up evaluations. Of the nondemented hallucinating PD patients nearly 70% showed impairment in multiple cognitive domains. The progressive decline in hallucinating PD patients affected mainly visual memory for faces and visuoperceptive-visuospatial functions. CONCLUSION: Our results support a fast impairment of complex visual functions in hallucinating PD patients, but also a progressive decline in multiple cognitive domains, which have been identified as a risk of developing dementia in PD.
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