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  • Title: [Involvement of nitric oxide in the mechanism of adrenergic responses of systemic circulation].
    Author: Osadchiĭ LI, Balueva TV, Sergeev IV.
    Journal: Izv Akad Nauk Ser Biol; 2007; (1):45-50. PubMed ID: 17352199.
    Abstract:
    Increased pressor response to the infusion of alpha1-adrenoceptor agonist phenylephrine was observed in conditions of inhibited NO synthesis: the mean blood pressure increased from 33.7 to 41.1% and the total peripheral resistance increased from 6.8 to 22.0%. The effect of vasodilation induced by NO secretion in the vascular endothelium after the stimulation by alpha1-adrenoceptors on the degree of pressor changes and changes in the total peripheral resistance is proposed.
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