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  • Title: [Effects of Chinese Bushen Zhuanggu medicine on bone loss in female rats after simulated weightlessness].
    Author: Sun P, Huang Z, Cai DH, He L.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2007 Feb; 27(2):212-4. PubMed ID: 17355940.
    Abstract:
    OBJECTIVE: To study the effect of Bushen Zhuanggu, the traditional Chinese medicine for reinforcing kidney and strengthening bone, on bone loss in female rats after simulated weightlessness. METHOD: Thirty-six female SD rats were randomly divided into 3 groups, namely normal control group (group A) and two groups of weightlessness simulated by tail suspension (groups B and C). Group C were treated with the Chinese medicine, while groups A and B were given the same dose of normal saline. The experiment lasted 28 days, and all rats were allowed to drink water freely. RESULTS: In the rats of group B, serum bone Gla protein (BGP), alkaline phosphatase (ALP), estradiol (E(2)) and P content and femur bone mineral content (BMD) were significantly lower than those in group A (P<0.01, P<0.05), whereas serum calcium concentration was markedly higher than that in group A (P<0.01). In rats of group C, serum BGP, ALP, E2 and P content and femur BMD were significantly higher than those in group B (P<0.01, P<0.05), but serum calcium concentration was markedly lower (P<0.01). CONCLUSION: This Chinese prescription can stimulate bone formation and reduce bone loss in female rats subjected to simulated weightlessness.
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