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  • Title: Possible role of sarA in dehydroepiandrosterone-mediated increase in Staphylococcus aureus resistance to vancomycin.
    Author: Plotkin BJ, Konaklieva M.
    Journal: Chemotherapy; 2007; 53(3):181-4. PubMed ID: 17356267.
    Abstract:
    BACKGROUND: Dehydroepiandrosterone (DHEA), a steroid present throughout life, can induce an increase in resistance to vancomycin in methicillin-sensitive and methicillin-resistant clinical isolates of Staphylococcus aureus. METHODS: The in vitro effect of DHEA on vancomycin killing of S. aureus with mutations in sarA and/or agr was determined by standard microtiter protocols and time to kill determinations. RESULTS: Of the isolates tested, the strain with a deletion in sarAderived from a DHEA- responsive parent was not protected from vancomycin killing by DHEA. However, DHEA significantly (p < 0.01) slowed the rate of vancomycin killing of sarA-. CONCLUSION: These data indicate that sarA may play a role in DHEA-mediated protection from vancomycin killing of S. aureus.
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