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  • Title: Serial quantitative diffusion tensor MRI of the term neonates with hypoxic-ischemic encephalopathy (HIE).
    Author: Malik GK, Trivedi R, Gupta RK, Hasan KM, Hasan M, Gupta A, Pandey CM, Narayana PA.
    Journal: Neuropediatrics; 2006 Dec; 37(6):337-43. PubMed ID: 17357035.
    Abstract:
    AIM: To determine the altered pattern of fractional anisotropy (FA) and mean diffusivity (MD) change in brain parenchyma in serially studied neonates with mild or moderate hypoxic ischemic injury (HIE) within 7 days after birth and again at the age of three months. METHODS: Serial diffusion tensor imaging (DTI) was performed at two-time points in term neonates with mild (n = 7) and moderate (n = 10) HIE and age/sex-matched controls (n = 7). Neurodevelopmental outcome was assessed at the time of the 2nd study. RESULTS: On comparing FA and MD changes over time using two-way analysis of variance between neonates with HIE and controls, we observed significant differences in age-related FA increase (p < 0.05) in anterior limb of internal capsule and periventricular white matter of parietal, occipital, and temporal lobes. Significant differences in age-related MD decrease (p < 0.05) was observed in the caudate nuclei, and temporal white matter among these groups. Significant positive correlation was observed between neurodevelopmental outcome and FA. CONCLUSION: The results suggest that abnormal FA and MD values help in early and more accurate assessment of microstructural damage in HIE that may have predictive value for long-term neurofunctional outcome in these neonates.
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