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  • Title: [The regulation effect of interleukin-1 on expression of cartilage specificity gene Sox9 mRNA in the human intervertebral discs].
    Author: Zhao Y, Wang WB, Lu Y, Ge Y, Yu ZG, Xue F.
    Journal: Zhonghua Wai Ke Za Zhi; 2006 Dec 15; 44(24):1704-7. PubMed ID: 17359721.
    Abstract:
    OBJECTIVE: To assess the regulating effects of interleukin-1 (IL-1) on gene expression of cartilage specificity gene Sox9 and type II collagen mRNA in the human intervertebral discs. METHODS: RT-PCR were used to investigate the effects of IL-1 on gene expression of Sox9 and type II collagen mRNA in intervertebral discs cells cultures of embryo. RESULTS: The Sox9 and type II collagen mRNA in intervertebral discs were decreased progressively along with the addition concentrations of IL-1 than the controls. And the mRNA of Sox9 and type II collagen also markedly decreased with the time of culture. CONCLUSIONS: IL-1 could cause dose-dependent and time-dependent inhibition effects on Sox9 and type II collagen gene expression in human intervertebral discs.
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