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  • Title: Kounis syndrome secondary to amoxicillin/clavulanic acid use.
    Author: Tavil Y, Turfan M, Türkoğlu S, Abaci A.
    Journal: Int J Cardiol; 2008 Feb 20; 124(1):e4-7. PubMed ID: 17360053.
    Abstract:
    Myocardial injury and acute coronary syndrome have been rarely associated with amoxicillin/clavulanic acid intake. The responsible pathogenetic mechanism is described by an amplified mast cell degranulation inducing coronary artery spasm and/or acute myocardial infarction in susceptible individuals which is called Kounis syndrome. We report here a case of Kounis syndrome presented with acute coronary syndrome due to amoxicillin/clavulanic acid use. All other etiologies, including ischemic reinfarction were appropriately ruled out.
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